Molecular Lab Revenue Integrity: Defending Your Lab Against CLFS Rate Cuts

Beyond simple billing; we provide SALSA-ready RCM that protects NGS and PCR revenue through automated Z-Code mapping and audit-proof documentation.

Our expert molecular lab billing services achieve a 95%+ clean claim rate and 20% average revenue increase, helping labs, genetic testing facilities, and physicians streamline revenue cycles while focusing on patient care.

Challenges Molecular Labs Face in Billing

Billing for molecular diagnostics and genetic testing labs comes with unique challenges that can slow revenue, increase denials, and create compliance risks:

Complex CPT and HCPCS codes

Molecular pathology CPT codes (81200–81479), NGS panels (81445–81455), and PCR tests (87635)  often confuse.

Frequent denials

Common denial codes include CO-50, CO-97, PR-96, and CO-16, often due to missing prior authorization or documentation gaps.

Compliance requirements

Adhering to CLIA, CMS, OIG, and CAP standards is mandatory.

Prior authorization & payer-specific rules

Navigating coverage policies for NGS, PCR, and genetic tests can be complex.

Delayed reimbursements & high A/R

Inefficient RCM workflows lead to lost revenue and administrative burden.

Facing any of these issues? Let’s discuss.

Our Molecular Lab Billing Services

We provide comprehensive, compliance-driven molecular diagnostics reimbursement solutions, covering all aspects of laboratory billing:

Full-Cycle Molecular Lab RCM

Merged per requirement
a 72-hour clean claim submission for NGS, PCR, and genetic testing with automated status tracking, denial prevention, and payer follow-up.

CPT, PLA & Molecular Coding Accuracy

Expert handling of PLA codes vs CPT, molecular pathology codes, NGS panels, and PCR testing aligned to payer rules and medical necessity standards.

Eligibility Verification & Prior Authorization

Real-time benefit checks and authorization workflows to prevent denials before testing is performed.

Denial Management & Appeals

Root-cause denial analysis, payer-specific appeals, and documentation defense for high-value molecular claims.

A/R Management & Financial Reporting

Reduced A/R days (20–30 average) with transparent reporting on collections, denials, and payer performance.

AI-Powered Billing Automation

Streamline lab workflows, improve claim accuracy, and reduce administrative overhead.

Value-Based Care Compliance

Align billing with MIPS, MACRA, and CLIA standards for incentive optimization.

How Our Denial Management Workflow Reduces A/R Days

We follow a proven, technology-enabled workflow that drives faster payments and fewer rejections:

Detect Trends

AI identifies payer-specific denial patterns across claims.

Prioritize & Route

Denials are categorized and routed to specialists instantly.

Automate Appeals

RPA tools auto-populate appeal forms and upload documents.

Continuous Feedback

Insights are used to prevent repeat errors and update payer rules.

Our clients report up to a 40% reduction in A/R days after implementing our denial workflow.

Compliance and Regulatory Assurance

Every claim passes through CLIA, CMS, OIG, and CAP checks to ensure payment integrity and audit readiness.

Our compliance team conducts:

This provides your lab stays fully compliant and penalty-free while meeting all MACRA/MIPS quality benchmarks for incentive eligibility.

Types of Molecular Labs We Serve

Our solutions are flexible and customizable to suit your lab’s specialty and workflow:
Your specialty is unique — so is our RCM approach.

How We Work – Streamlined, Transparent, Secure

Our approach ensures efficiency, transparency, and reliability at every step:

Dedicated Account Management

A single point of contact for smooth communication.

Seamless LIS/EHR Integration

Epic Beaker, Cerner, Meditech, Sunquest, LabWare, and others.

Proactive Denial Prevention

AI-driven scrubbing tools prevent claim denials before submission.

Transparent Reporting & Audit-Ready Documentation

Stay compliant and informed with actionable insights.

Flexible, Scalable Solutions

Outsourced molecular lab billing services tailored to lab volume.

The right solution? Your search ends here. We have a complete molecular lab billing made simple.

Frequently Asked Questions (FAQs)

How is molecular testing billed?
Using CPT codes 81200–81479 (molecular pathology), 81445–81455 (NGS), and 87635 (PCR), following payer rules and documentation.
Missing prior authorization, incomplete docs, incorrect CPTs, or payer restrictions.
Yes, HIPAA-compliant outsourcing ensures secure, accurate, and timely reimbursement.
Partner with RCM experts, maintain precise docs, use AI claim scrubbing, and follow payer policies.
Labs must stay CLIA-certified and comply with CMS rules to ensure payment and avoid penalties.

Ready to Optimize Your Molecular Lab Revenue?

Accelerate payments and streamline your molecular lab billing!